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Interaction of genetic and exposure factors in the prevalence of berylliosis

✍ Scribed by Luca Richeldi; Kathleen Kreiss; Margaret M. Mroz; Boguang Zhen; Pierluigi Tartoni; Cesare Saltini

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 32 KB
Volume: 32
Category: Article
ISSN: 0271-3586
DOI: 10.1002/(sici)1097-0274(199710)32:4<337::aid-ajim3>3.0.co;2-r

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✦ Synopsis

Prevalence of berylliosis, a lung disorder driven by the activation of beryllium-specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA-DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium-exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA-DPB1Glu69-positive machinists 25%; HLA-DPB1Glu69-negative machinists 3.2%, P 5 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process-related risk factors.

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