✦ LIBER ✦

Interaction of filarial proteins on growth regulation of normal lung epithelial cells in vitro

✍ Scribed by A. Maya; S. Usha; K. Jayaraman; Krishnan Baba; M. Sukumaran; A. Balakrishnan

Book ID: 102966148
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 866 KB
Volume: 19
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1995.1065

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✦ Synopsis

ABSTRACT

An in vitro model to examine the effects of filarial proteins on lung epithelial cells has been developed. Several of these proteins appear in circulation of infected individuals. A close association between tropical pulmonary eosinophilia (TPE) and filariasis has been reported by several workers. [^3^H]‐thymidine studies do indicate that when optimum concentration of these filarial proteins were added to lung cultures in proliferating and basal/maintenance media a further increase in growth stimulation was observed early in culture. However, on longer exposures and at higher concentrations an inhibitory effect with distinct morphological changes were noted. The dual role of these proteins on lung epithelial cells in vitro may highlight the possibility of a direct interaction of these proteins with lung cells during disease also contributing to tissue damage.

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