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Interaction of fibroblasts and polymer surfaces: relationship between surface free energy and fibroblast spreading

✍ Scribed by van der Valk, P. ;van Pelt, A. W. J. ;Busscher, H. J. ;de Jong, H. P. ;Wildevuur, Ch. R. H. ;Arends, J.

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
524 KB
Volume
17
Category
Article
ISSN
0021-9304

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✦ Synopsis

Cell spreading and cell division rates of a transformed line of mouse lung fibroblasts were studied on various polymer surfaces in the presence of serum proteins. The bare polymer surfaces, as well as the proteincoated surfaces, were characterized by their polar (7;) and dispersion (7%) surface free energies. Cell spreading appeared to be dependent on the polar surface free energy. Cell spreading is low when the 7 C of the bare surface is lower than 5 erg cm-2; marked spreading occurs when 7: is higher than 15 erg cm-2. A similar relationship was found between cell spreading and polarity of the protein-coated surfaces, although less pronounced than for the bare surfaces. Cell spreading appeared independent of the dispersion surface free energy. Cell division rate was the same on all surfaces tested.

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