Interaction of Estrogen Receptor α Transactivation Domain with MTA1 Decreases in Old Mouse Brain
✍ Scribed by M. K. Thakur; Swati Ghosh
- Book ID
- 107575104
- Publisher
- Humana Press Inc
- Year
- 2008
- Tongue
- English
- Weight
- 174 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0895-8696
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## Abstract After the interaction of estrogen with the ligand binding domain (LBD) of mouse estrogen receptor‐α (mERα) and hormone‐responsive elements of target genes, many nuclear proteins are recruited to regulate the expression of specific genes. Because it is not known which brain proteins inte
## Abstract Estrogen receptor (ER)‐α interacts with nuclear proteins to mediate its multiple functions in the brain. However, it is not known which proteins interact with the ERα‐transactivation domain (TAD) in mouse brain and whether they change with age and sex. Therefore, we have used affinity‐p