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Interaction of DNA/Polycation Complexes with Phospholipids: Stabilizing Strategy for Gene Delivery

✍ Scribed by Arkadi Zintchenko; Čestmír Koňák

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
117 KB
Volume
5
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Summary: The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes.

Interaction of DNA/polycation complex particles with lipid vesicles.

magnified imageInteraction of DNA/polycation complex particles with lipid vesicles.

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