Interaction of dimethylsulfoxide and arachidonic acid with the teratogenic effects of caffeine in mice
โ Scribed by Rajasekhar V. Reedy; Dr. Chada S. Reedy; Brian L. Fraipier; Gary E. Brimer
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 820 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1056-9014
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
This study was undertaken to investigate if dimethylsulfoxide (OMSO)-induced potentiation of maternal toxicity and teratogenicity of caffeine (CAI is mediated by DMSO-induced alteration of CA levels in maternal and fetal tissues. Pregnant CD 1 mice were given single dose of [l4C1-caffeine intraperit
The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. Treatment of pregnant dams (600 mg/kg sodium valproate in distilled water, i.p.) during
## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a
BACKGROUND: Epidermal growth factor (EGF) and transforming growth factor-โฃ (TGFโฃ) regulate cell proliferation and differentiation in the embryo. The induction of cleft palate (CP) by all trans-retinoic acid (RA) was associated with altered expression of TGFโฃ, EGF receptor, and binding of EGF. This s