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Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity

โœ Scribed by Vivek S. Purohit; Sathyamangalam V. Balasubramanian


Publisher
American Association of Pharmaceutical Scientists
Year
2006
Tongue
English
Weight
262 KB
Volume
8
Category
Article
ISSN
1550-7416

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Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act

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