Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act
Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity
โ Scribed by Vivek S. Purohit; Sathyamangalam V. Balasubramanian
- Publisher
- American Association of Pharmaceutical Scientists
- Year
- 2006
- Tongue
- English
- Weight
- 262 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1550-7416
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๐ SIMILAR VOLUMES
Factor VIII is a multi-domain glycoprotein and is an essential cofactor in the blood coagulation cascade. Its deficiency or dysfunction causes Hemophilia A, a bleeding disorder. Replacement using exogenous recombinant Factor VIII (FVIII) is the first line of therapy for Hemophilia A. Immunogenicity,
Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg