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Interaction of clozapine with the histamine H3 receptor in rat brain

✍ Scribed by A. Alves Rodrigues; F.P. Jansen; R. Leurs; H. Timmerman; G.D. Prell

Book ID
117960166
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
365 KB
Volume
114
Category
Article
ISSN
0007-1188

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Following up h e finQng that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activiryl 1.21 , a scrim of analogues and metabolites (clorapinc-N-oxide. and N-desmcthylclozapine) were tested for thcir affinity towards thc H3 receptor using the radiolabelled H,