Interaction of calmodulin with a putative calmodulin-binding domain of inositol 1,4,5-triphosphate 3-kinase. : Effects of synthetic peptides and site-directed mutagenesis of Trp165

Synthetic D- and L-enantiomers of 2,2-di

Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: Identification of a potent small molecule 3-kinase inhibitor

✍ Stephen T. Safrany; Deborah A. Sawyer; Stefan R. Nahorski; Barry V.L. Potter 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 684 KB

The ability of two enantiomeric fluoro-analogues of D-myo-inositol 1,4,5trisphosphate [Ins(1,4,5)P3] to mobilize intracellular Ca2+ stores in SH-SY5Y neuroblastoma cells has been investigated. ( -)-~-2,2-difluoro-2-deoxy-myo-Ins(1,4,5)P~ [~-2,2-F2 -Ins(1,4,5)P3] was a full agonist [ECm 0.21 pA4l and