Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles
β Scribed by Van de Waart, Piet; Bruls, Harry; Hemker, H. Coenraad; Lindhout, Theo
- Book ID
- 127098564
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 791 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0006-2960
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π SIMILAR VOLUMES
Phospholipid monolayers adsorbed at the air-water interface are useful model membranes and have been employed to study the interactions between phospholipids and blood clotting factors I and VII. Factor I is a non-membrane-binding protein and was found to penetrate both distearoylphosphatidylcholine
Blood coagulation factor X (FX) is converted to its active form (FXa) by a membrane bound multi-protein enzyme complex, comprised of factor VIII (FVIII), factor IXa (FIXa) and FX. Characterization of the molecular forces involved in the association of these proteins with phospholipids is crucial to