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Interaction of bleomycin with a methylated DNA oligonucleotide

✍ Scribed by Long, Eric C.; Hecht, Sidney M.; Van der Marel, Gijs A.; Van Boom, Jacques H.


Book ID
126823182
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
680 KB
Volume
112
Category
Article
ISSN
0002-7863

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## Abstract The novel analogues **11**–**16** of bleomycin A~6~ (**3**) were obtained by selective protection of the primary‐amine function of the __Ξ²__‐aminoalaninamide moiety of **3** by means of coordination with Cu^II^ ions, condensation with an aliphatic or aromatic acid Rβ€²COOH in the presence