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Interaction of Antiepileptic Drugs with Human P-Glycoprotein in Vitro

✍ Scribed by Weiss, J.


Book ID
121785661
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2003
Tongue
English
Weight
187 KB
Volume
307
Category
Article
ISSN
0022-3565

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The drug transporter P-glycoprotein (P-gp) influences drug distribution across the blood-brain barrier (BBB) by actively extruding drugs into the neural capillaries. Several psychotropic drugs, including nortriptyline (NT) and risperidone (Risp), are substrates of P-gp. Here we compared the in vitro