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Interaction of antidepressant drugs with guinea pig histamine H2-receptors studied with [125I]iodoaminopotentidine, a high affinity and selective ligand

✍ Scribed by E. Traiffort; M. Ruat; J.C. Schwanz; J. Hirschfeld; W. Schunack


Book ID
115884259
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
87 KB
Volume
183
Category
Article
ISSN
0014-2999

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## Abstract [^3^H]TCP, an analog of the dissociative anesthetic phencyclidine (PCP), binds with high affinity to two sites in guinea pig brain membranes, one that is MK‐801 sensitive and one that is not. The MK‐801‐sensitive site (PCP site 1) is associated with NMDA receptors, whereas the MK‐801‐in