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Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells

✍ Scribed by Jacques Dupuy; Michel Alvinerie; Cecile Ménez; Anne Lespine


Book ID
113518229
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
222 KB
Volume
186
Category
Article
ISSN
0009-2797

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To date, research on the effect of single nucleotide polymorphisms (SNPs) on P-glycoprotein (P-gp) expression and functionality has rendered inconsistent results. This study systematically evaluates the impact of MDR1 haplotypes (1236/2677, 1236/3435, 2677/3435, 1236/2677/3435) on P-gp functionality