A convenient synthesis of coumarin-3-car
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Aimin Song; Xiaobing Wang; Kit S Lam
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Article
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2003
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Elsevier Science
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French
⚖ 119 KB
Coumarin-3-carboxylic acids were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol. The less reactive ketones were first reacted with alcoholic ammonia to form ketimines, which were then condensed with Meldrum's acid to gen