Interaction of a Self-Assembling Peptide with Oligonucleotides: Complexation and Aggregation
β Scribed by Wang, Mei; Law, Maggie; Duhamel, Jean; Chen, P.
- Book ID
- 119921005
- Publisher
- Biophysical Society
- Year
- 2007
- Tongue
- English
- Weight
- 584 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0006-3495
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## Abstract In this work we have probed the interactions of the amyloid AΞ²(1β42) peptide with selfβassembled nanospheres. The nanospheres were formed by selfβassembly of a newly developed bolaamphiphile bis(__N__βalphaβamidoβmethionine)β1,8 octane dicarboxylate under aqueous conditions. It was foun
Peptide P 11 -4 (QQRFEWEFEQQ) was designed to self-assemble to form b-sheets and nematic gels in the pH range 5-7 at concentrations !12.6 mM in water. This self-assembly is reversibly controlled by adjusting the pH of the solvent. It can also self-assemble into gels in biological media. This togethe