Overexpression of epidermal growth factor receptor (EGFr) has been demonstrated on many human tumors, and the increase in receptor expression levels has been linked with a poor clinical prognosis. Blocking the interaction of EGFr and the growth factors could lead to the arrest of tumor growth and po
Interaction of a monoclonal antibody against hEGF with a receptor site for EGF
✍ Scribed by Sonia Valente; Beatriz Souto; Henia Balter; Mick M Welling; Estela Román; Ana Robles; Ernest K.J Pauwels
- Book ID
- 117688411
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 260 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0969-8051
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## Abstract A truncated epidermal growth factor receptor (EGFR) expressed from a rearranged and amplified EGFR gene is present at high frequency in gliomas. In this work we show that when this receptor is expressed in NIH3T3 fibroblasts it is partially activated and confers tumorigenicity to this c
The prognostic significance of the epidermal growth factor receptor status (EGF-R-status) for certain human tumors requires the development of antibodies useful for clinical application. We used purified receptor preparations to generate monoclonal antibodies immunoreactive with the EGF-R purified f