Interaction of 3,4-benzpyrene with monomolecular films

✍ Scribed by A. Felmeister; D. Tsai; N. D. Weiner

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 386 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610705

✦ Synopsis

The interactions of the carcinogenic hydrocarbon, 3,4benzpyrene [benz(a)pyrene], with cholesterol, phospholipid, protein, and lipid-protein films were investigated. Whereas the interaction between 3,4benzpyrene and cholesterol was weak, the interaction between the carcinogen and dipalmitoyl lecithin was very strong, as determined from surface pressure-surface area data. The extent of the interaction between the phospholipid and 3,4benzpyrene was dependent on the mole fraction of each component in the film. 3,CBenzpyrene was shown also to interact strongly with protein films and mixed lipid-protein films. In the case of the latter films, the extent of interaction was dependent on whether or not the lipid was first allowed to interact with the protein before the carcinogen was added. The biological significance of these data is discussed.

Keyphrases 0 3,CBenzpyrene-interaction with various monomolecular films, biological significance 0 Monomolecular filmsinteraction of 3,4-benzpyrene with various cholesterol, phospholipid, protein, and lipid-protein films, biological significance 0 Carcinogenic hydrocarbons-interaction of 3,4-benzpyrene with various monomolecular films, biological significance