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Interaction network containing conserved and essential protein complexes in Escherichia coli

✍ Scribed by Butland, Gareth; Peregrín-Alvarez, José Manuel; Li, Joyce; Yang, Wehong; Yang, Xiaochun; Canadien, Veronica; Starostine, Andrei; Richards, Dawn; Beattie, Bryan; Krogan, Nevan

Book ID
109893761
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
606 KB
Volume
433
Category
Article
ISSN
0028-0836

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The proteome, a set of proteins expressed in an organism, is organized in an intricate web called the protein-protein interaction (PPI) network. In this article we propose a topological parameter called damage, that measures the consequences of the deletion of a protein from the network. We investig