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Interaction energy studies of pyrrolopyrimidine nucleoside antibiotics: Sangivamycin

โœ Scribed by Nitish K. Sanyal; Rajendra Prasad Ojha; M. Roychoudhury; S. N. Tiwari

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
389 KB
Volume
7
Category
Article
ISSN
0192-8651

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โœฆ Synopsis

Interaction energy calculations have been employed to study the biological activity of sangivamycin. The interaction energy values and the site of association of the analog have been compared with those for the nucleic acid bases. A comparative estimation of the results with those of other pyrrolopyrimidine nucleosides (Tubercidin and Toyocamycin) has been made. These studies suggest that the activity of pyrrolopyrimidine analogs is of the following order Toyocamycin > Tubercidin > Sangivamycin which is in general agreement with the experimental results.

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