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Interaction between prostaglandins and selective phosphodiesterase inhibitors in isolated guinea-pig trachea in vitro

✍ Scribed by Steffen Thirstrup; Ronald Dahl; Folmer Nielsen-Kudsk

Book ID
119414002
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
97 KB
Volume
333
Category
Article
ISSN
0014-2999

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro