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Interaction between methylxanthine and cardioactive drugs

✍ Scribed by V. Jakovljevic; A. Sabo; M. Popovic; M. Stanulovic


Book ID
115885591
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
115 KB
Volume
183
Category
Article
ISSN
0014-2999

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Lethal drug interaction: Isoniazid and m
✍ Cynthia M. Harris; Angela C. Springfield; Erik R. Ranschaert; Dr. Harbans Lal πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 320 KB

Nonlethal doses of methylxanthines (caffeine or theophyline) produced dose-dependent lethality in rats pretreated with isoniazid. lsoniazid pretreatment did not alter theophylline concentration in blood or brain, suggesting that the drug interaction was not due to altered distribution or metabolism