Interaction between HLA-DR and HLA-DP, and Between HLA and interleukin 1α in juvenile rheumatoid arthritis indicates heterogeneity of pathogenic mechanisms of the disease
✍ Scribed by Rafal Ploski; Tarra L. McDowell; Julian A. Symons; Berit Flatø; Gordon W. Duff; Erik Thorsby; Øystein Førre
- Book ID
- 116113945
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 440 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0198-8859
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Objective. To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. Met
## Abstract ## Objective The main genetic risk factor for rheumatoid arthritis (RA) is the shared epitope (SE) of HLA–DR, while smoking is an important environmental risk factor. We studied a potential gene–environment interaction between SE genes and smoking in the etiology of the 2 major subgrou