Interaction among vitamin D3 analogue KH 1060, TNF-α, and vitamin D receptor protein in peripheral blood mononuclear cells of inflammatory bowel disease patients

Vitamin D derivatives induce apoptosis a

Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients

✍ Maria Martinesi; Cristina Treves; Giuseppe d'Albasio; Siro Bagnoli; Andrea G. Bo 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB 👁 1 views

## Background: Lymphocytes are crucial in the pathogenesis of inflammatory bowel disease (ibd) and are an important target for drug development. our aim was to verify whether 2 vitamin d derivatives, 1,25-dihydroxyvitamin d3 [1,25(oh)2d3] and eb 1089, could induce cell apoptosis and affect cell-cel