Three-Component Tandem Knoevenagel/Heter
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Giovanni Appendino; Giancarlo Cravotto; Alberto Minassi; Giovanni Palmisano
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Article
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2001
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John Wiley and Sons
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English
⚖ 325 KB
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Starting from 4-hydroxy-5-methylcoumarin ( 7), (±)-preethulia coumarin (3) was synthesized in six steps and in 4% overall yield. The key synthetic procedure was a new type of Lewis acid catalysed, three-component Knoevenagel/hetero Diels-Alder reaction, which employs α-dicarbonyl com-Over the past f