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Intensive chemotherapy with idarubicin, cytosine arabinoside, and granulocyte colony-stimulating factor (G-CSF) in patients with secondary and therapy-related acute myelogenous leukemia

✍ Scribed by Gardin, C; Chaibi, P; de Revel, T; Rousselot, P; Turlure, P; Micléa, J M; Nédellec, G; Dombret, H

Book ID: 110053396
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 78 KB
Volume: 11
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2400536

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GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of