## Abstract Human intestinal epithelial cell survival and anoikis are distinctively regulated according to the state of differentiation. In the present study, we analyzed the roles of focal adhesion kinase (Fak)/Src signaling to the PI3‐K/Akt‐1 and mitogen‐activated protein kinase (MEK)/extracellul
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
✍ Scribed by Marco Beauséjour; Dominique Noël; Sonya Thibodeau; Véronique Bouchard; Charlène Harnois; Jean-François Beaulieu; Marie-Josée Demers; Pierre H. Vachon
- Book ID
- 113061108
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 649 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1360-8185
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs). We report that: (1) cancer cells display striking anoi
To investigate the mechanisms responsible for survival and apoptosis/anoikis in normal human intestinal epithelial crypt cells, we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl-2 homologs (Bcl-2, Bcl-XL, Mcl-1, Bax, Bak, Bad) in the well established