Long-term administration of pharmacological doses of glucocorticoids inhibits bone formation and results in osteoporosis. Since integrin-mediated cell-matrix interactions are essential for osteoblast function, we hypothesized that the detrimental effect of glucocorticoids on bone derived, at least i
Integrin αv in the mechanical response of osteoblast lineage cells
✍ Scribed by Kaneko, Keiko; Ito, Masako; Naoe, Yoshinori; Lacy-Hulbert, Adam; Ikeda, Kyoji
- Book ID
- 122299841
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 569 KB
- Volume
- 447
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Previous studies have demonstrated that both mechanical perturbation and cell adhesion induced the expression of osteopontin (__opn)__ by osteoblasts (Carvalho et al. [1998] J. Cell. Biochem. 70:376–390). The present study examined if these same stimuli on osteoblasts would induce the e