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Integrin αIIbβ3:ligand interactions are linked to binding-site remodeling

✍ Scribed by Roy R. Hantgan; Mary C. Stahle; John H. Connor; David A. Horita; Mattia Rocco; Mary A. McLane; Sergiy Yakovlev; Leonid Medved

Book ID
111752675
Publisher
Cold Spring Harbor Laboratory Press
Year
2006
Tongue
English
Weight
706 KB
Volume
15
Category
Article
ISSN
0961-8368

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## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on