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Integrin-dependent translational control: Implication in cancer progression

✍ Scribed by Jun Chung; Tae Hyong Kim

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
113 KB
Volume
71
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

The importance of translational control in cancer progression has been underscored by a number of recent studies. However, little is known how cancer cells maintain their high efficiency of translation. Here, we summarize studies that support the role of integrins in translational control, especially at the initiation step, and discuss the various mechanisms by which integrins regulate the recruitment of translational machinery. This review also examines the hypothesis that integrins contribute to various aspects of cancer progression such as proliferation, survival, angiogenesis, and invasion through translational control. Microsc. Res. Tech. 2008. © 2008 Wiley‐Liss, Inc.

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