Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1

Integrin cytoplasmic domain-associated p

Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane

✍ Peter J.M. Stroeken; Belén Alvarez; Jacco van Rheenen; Yvonne M. Wijnands; Dirk 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB

## Abstract The integrin cytoplasmic domain‐associated protein‐1 (ICAP‐1) binds via its C‐terminal PTB (phosphotyrosine‐binding) domain to the cytoplasmic tails of β1 but not other integrins. Using the yeast two‐hybrid assay, we found that ICAP‐1 binds the ROCK‐I kinase, an effector of the RhoA GTP