The survival, proliferation and differentiation of neuroblastoma (NB) cells are largely dependent on adhesion to extracellular matrix (ECM) proteins. Integrin occupancy seems to play a primary role. To elucidate the role of integrin heterodimers during neuronal cell death, we have analysed the chang
β¦ LIBER β¦
Integrin and cytoskeleton behaviour in human neuroblastoma cells during hyperthermia-related apoptosis
β Scribed by F. Luchetti; F. Mannello; B. Canonico; M. Battistelli; S. Burattini; E. Falcieri; S. Papa
- Book ID
- 111571449
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 786 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1360-8185
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## Abstract The potent antiapoptotic molecule Bclβ2 is markedly upβregulated in a majority of cancers, including neuroblastoma. Genistein is an isoflavone with antitumor properties. The present study sought to elucidate the molecular mechanism of genisteinβinduced apoptosis and also to examine the