Epidermal growth factor (EGF) stimulates the growth of several types of epithelial tissues and possesses a strong mitogenic activity that is mediated through its cell surface receptor (EGFR). The aim of this study was to characterize EGFR and measure its levels in head and neck tumors biopsies (70 p
Integrating Epidermal Growth Factor Receptor Assay With Clinical Parameters Improves Risk Classification for Relapse and Survival in Head-and-Neck Squamous Cell Carcinoma
โ Scribed by Christine H. Chung; Qiang Zhang; Elizabeth M. Hammond; Andy M. Trotti III; Huijun Wang; Sharon Spencer; Hua-Zhong Zhang; Jay Cooper; Richard Jordan; Marvin H. Rotman; K. Kian Ang
- Book ID
- 118455152
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 605 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0360-3016
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## Abstract Noninvasive imaging of the epidermal growth factor receptor (EGFR) in headโandโneck squamous cell carcinoma could be of value to select patients for EGFRโtargeted therapy. We assessed dose optimization of ^111^IndiumโDTPAโcetuximab (^111^Inโcetuximab) for EGFR imaging in a headโandโneck
Numerous reports have shown an association between overexpression of the epidermal growth factor receptor (EGFR), and poor prognosis in head and neck squamous cell carcinomas (HNSCC), however, the underlying mechanisms are still unclear. In the present study, we set out to determine whether EGFR exp