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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

✍ Scribed by Hubner, Norbert; Wallace, Caroline A; Zimdahl, Heike; Petretto, Enrico; Schulz, Herbert; Maciver, Fiona; Mueller, Michael; Hummel, Oliver; Monti, Jan; Zidek, Vaclav


Book ID
109919124
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
496 KB
Volume
37
Category
Article
ISSN
1061-4036

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## Abstract Sly disease (MPS VII) is an autosomal‐recessive lysosomal storage disorder resulting from beta‐glucuronidase deficiency, which is characterized by a severe neurological impairment. MPS VII mice accumulate undegraded glycosaminoglycans and mimic the human neurodegenerative disorder, thus