Integrated sensor-telemetry system for in vivo glucose monitoring

✍ Scribed by Joseph Black; Michael Wilkins; Plamen Atanasov; Ebtisam Wilkins

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 627 KB
• Volume: 31
• Category: Article
• ISSN: 0925-4005
• DOI: 10.1016/0925-4005(96)80059-1

✦ Synopsis

This paper reports the development of an electronics package designed for use with an implantable amperometric glucose biosensor. The package includes a potentiostat to bias the sensor and a telemetry unit to transmit information from the sensor to an external receiver and datacollection computer. The device components and package have been evaluate6 in vitro. Initial tests are performed with non-encapsulated electronics and the sensor partly submerged in a glucose solution. To simulate the implantation conditions, tests have been conducted with the electronics encapsulated in plastic (epoxy resin or silicone elastomer matrix) and submerged in a 37 °C water bath. These tests verify that the telemetry system is transmitting through an aqueous solution with a water mass equivalent to a medium sized dog. Calibration curves of the received signal versus glucose concentration in model solutions have been obtained. The correlation between data obtained using a traditional potentiostat and the data obtained via telemetry allows the commencement of in rive experimentation.