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Integrated pharmacokinetic–pharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody

✍ Scribed by Jorge Duconge; Rubén Castillo; Tania Crombet; Daniel Alvarez; Janet Matheu; Gloria Vecino; Katia Alonso; Irene Beausoleil; Carmen Valenzuela; Maria A Becquer; Eduardo Fernández-Sánchez

Book ID: 113591263
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 181 KB
Volume: 21
Category: Article
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2003.10.015

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Interspecies scaling of the monoclonal a

Interspecies scaling of the monoclonal anti-EGF receptor ior EGF/r3 antibody disposition using allometric paradigm: is it really suitable?

✍ Jorge Ducongé; Eduardo Fernández-Sánchez; Daniel Alvarez 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract The pharmacokinetic regularity of the murine monoclonal antibody ior EGF/r3 across mammals was studied using allometry. The allometric relationship between the volume of distribution and body weight (__W__) across mammalian species was characterized by the power equation __V__~d~=218.8