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Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins

✍ Scribed by Aleksandra Walewska; Min-Min Zhang; Jack J. Skalicky; Doju Yoshikami; Baldomero M. Olivera; Grzegorz Bulaj

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 379 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200806085

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## Abstract Small disulfide‐rich peptides are translated as larger precursors typically containing an N‐terminal prepro sequence. In this study, we investigated the role of a propeptide in the oxidative folding of an extremely hydrophobic δ‐conotoxin, PVIA. δ‐Conotoxin PVIA (δ‐PVIA) is a 29‐amino a