✦ LIBER ✦
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum
✍ Scribed by Amit K. Gupta; Shruti Saxena; Mridula Saxena
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 674 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
A common feature pharmacophore with two hydrogen-bond acceptor and one aromatic hydrophobic feature has been generated using seven active flavonoids. Docking studies of these compounds well corroborates with the pharmacophore model. Therefore models could be useful for identification of potential novel FAS-II inhibitors.