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Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers

✍ Scribed by Eleni Efstathiou; Maria Karlou; Sijin Wen; Anh Hoang; Curtis A. Pettaway; Louis L. Pisters; Sankar Maity; Patricia Troncoso; Christopher J. Logothetis


Book ID
112179676
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
409 KB
Volume
73
Category
Article
ISSN
0270-4137

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## Abstract Although the blockade of the hedgehog cascade by using cyclopamine has been reported to inhibit the growth of some cancer cell types, few studies on the mechanism by which this drug alone or in combination with other cytotoxic agents induces its cytotoxic effect have been reported. In o