𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder

✍ Scribed by Altemus, Margaret; Murphy, Dennis L.; Greenberg, Benjamin; Lesch, K. Peter

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
372 KB
Volume
67
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

Epidemiologic studies indicate that obsessivecompulsive disorder is genetically transmitted in some families, although no genetic abnormalities have been identified in individuals with this disorder. The selective response of obsessive-compulsive disorder to treatment with agents which block serotonin reuptake suggests the gene coding for the serotonin transporter as a candidate gene. The primary structure of the serotonintransporter coding region was sequenced in 22 patients with obsessive-compulsive disorder, using direct PCR sequencing of cDNA synthesized from platelet serotonintransporter mRNA. No variations in aminoacid sequence were found among the obsessive-compulsive disorder patients or healthy controls. These results do not support a role for alteration in the primary structure of the coding region of the serotonin-transporter gene in the pathogenesis of obsessive-compulsive disorder.

πŸ“œ SIMILAR VOLUMES

Comprehensive family-based association s
Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder
✍ Jack Samuels; Ying Wang; Mark A. Riddle; Benjamin D. Greenberg; Abby J. Fyer; Ja πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 151 KB πŸ‘ 1 views

## Abstract SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessive‐compulsive disorder (OCD). Several independent research groups have reported significant associations between OCD and single nucleotide polymorphisms (SNPs) in this gene. Previously, we evalu

Lack of relationship between CO2 reactiv
Lack of relationship between CO2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder
✍ Perna, Giampaolo ;Bella, Daniela di ;Favaron, Elisa ;Cucchi, Michele ;Liperi, La πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 57 KB πŸ‘ 1 views

Changes in the function of the serotonergic system influence both panic phobic symptoms and carbon dioxide (CO2) reactivity in patients with panic disorder. Schmidt et al. [2000: J Abnorm Psychol 109(2):308-320] recently reported a predictive role of the genetic variants of the 5-HTTLPR on the fearf