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Insulin's structural behavior and its relation to activity

✍ Scribed by E. J. Dodson; G. G. Dodson; R. E. Hubbard; C. D. Reynolds

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
562 KB
Volume
22
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

This paper discusses the hypothesis that insulin undergoes a conformational change either before or during its binding to the receptor. The evidence for this is not conclusive but allows us to reconcile the following observations: (1) no chemical modification or deletion of invariant surface residues has abolished the hormone's activityβ€”only reduced its potency. (2) Reduction in potency follows many modifications to different side chains, both variant and invariant. (3) There are insulins with perfectly preserved structure (by the criteria of aggregation, spectroscopy, and x‐ray analysis) that have markedly reduced potency. (4) Insulins with disturbed structure still exhibit real, sometimes substantial activity.

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