𝔖 Bobbio Scriptorium
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Insulin Therapy and its Shortcomings – the Need for New Approaches

✍ Scribed by F.W. Whitehouse

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
127 KB
Volume
14
Category
Article
ISSN
0742-3071

No coin nor oath required. For personal study only.

✦ Synopsis

After its discovery in 1921, insulin rapidly became established as a treatment for insulinrequiring diabetes mellitus (Type 1 and late-stage Type 2), providing effective symptom control and significant reductions in diabetes-associated mortality. However, within 30 years of insulin's discovery, physicians were faced with a new challenge -the treatment of the long-term complications of chronic hyperglycaemia. The Diabetes Control and Complications Trial provided clear evidence of the benefits of improved glycaemic control, but also highlighted the difficulties, such as an increased risk of hypoglycaemia, of attempting to achieve this using insulin as the only pharmacological agent. We now know that the pancreatic islet hormone, amylin, is also deficient in patients with Type 1 and late-stage Type 2 diabetes. It is possible that parallel replacement of both amylin and insulin may improve glycaemic control more smoothly in patients with diabetes, with less risk of hypoglycaemia, while still reducing the long-term sequelae of chronic hyperglycaemia.

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