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Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor

✍ Scribed by Doru V Chirieac; Joanne Cianci; Heidi L Collins; Janet D Sparks; Charles E Sparks


Book ID
117052531
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
95 KB
Volume
297
Category
Article
ISSN
0006-291X

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Degradation of the LDL receptors by PCSK
✍ Øystein L Holla; Jamie Cameron; Knut Erik Berge; Trine Ranheim; Trond P Leren πŸ“‚ Article πŸ“… 2007 πŸ› BioMed Central 🌐 English βš– 506 KB

## Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 activates another protein that in turn causes degradation of the LDLR. ## Res