Rapid validation of cancer genes in chim
โ
Ivo J. Huijbers; Paul Krimpenfort; Anton Berns; Jos Jonkers
๐
Article
๐
2011
๐
John Wiley and Sons
๐
English
โ 320 KB
Recent technological advances have opened the door for the fast and cost-effective generation of genetically engineered mouse models (GEMMs) to study cancer. We describe here a conceptually novel approach for the generation of chimeric GEMMs based on the controlled introduction of various genetic el