Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
✍ Scribed by Sónia C. Correia; Renato X. Santos; Cristina Carvalho; Susana Cardoso; Emanuel Candeias; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira
- Book ID
- 113505983
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 652 KB
- Volume
- 1441
- Category
- Article
- ISSN
- 0006-8993
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This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
## Abstract We have evaluated the effect of peripheral insulin deficiency on brain insulin pathway activity in a mouse model of type 1 diabetes, the parallels with Alzheimer's disease (AD), and the effect of treatment with insulin. Nine weeks of insulin‐deficient diabetes significantly impaired the