𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Insulin sensitivity of liver glycogen synthasebintoaconversion

✍ Scribed by Alvin H. Gold; David Dickemper; Doris M. Haverstick

Publisher
Springer
Year
1979
Tongue
English
Weight
1005 KB
Volume
25
Category
Article
ISSN
0300-8177

No coin nor oath required. For personal study only.

✦ Synopsis

Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in vitro system using exogenous isolated phospho-enzyme as substrates with added phosphatases. Synthase and phosphorylase phosphatases were shown to have differential catalytic properties by their reactivity in the presence of Pi, the heat-stable inhibitor of phosphorylase phosphatase and after incubation with added cAMP-dependent protein kinase.

πŸ“œ SIMILAR VOLUMES

Liver and muscle insulin sensitivity, gl
Liver and muscle insulin sensitivity, glycogen concentration and glycogen synthase activity in a rat model of non-insulin-dependent diabetes
✍ Y. T. Kruszynska; P. D. Home πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 618 KB

Mild diabetes was induced in adult rats with streptozotocin (45 mg/kg body weight), and insulin sensitivity, glycogen deposition and glycogen synthase activity assessed in liver and muscle 5 weeks later. Diabetic rats had significantly elevated fasting blood glucose concentrations (5.6 +/- 0.1 versu

Post-marathon Paradox in IDDM: Unchanged
Post-marathon Paradox in IDDM: Unchanged Insulin Sensitivity in Spite of Glycogen Depletion
✍ Tuominen, J.A.; Ebeling, P.; Vuorinen-Markkola, H.; Koivisto, V.A. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 179 KB

Acute physical exercise usually enhances insulin sensitivity. We examined the effect of a competitive 42 km marathon run on glucose uptake and lipid oxidation in 7 runners with insulin-dependent diabetes mellitus (IDDM), aged 36 +/- 3 yr, BMI 23.9 +/- 0.5 kg m-2, VO2max 46 +/- 1 ml kg-1 min-1, HbA1c

Hepatic insulin gene therapy diminishes
Hepatic insulin gene therapy diminishes liver glycogen despite insulin responsive transcriptional effects in diabetic CD-1 mice
✍ Jin-an Zhang; Dingwu Jia; Darin E. Olson; Adam G. Campbell; Peter M. ThulΓ© πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 228 KB

## Abstract ## Background Hepatic insulin gene therapy (HIGT) produces near‐normal glycemia in diabetic rats. Hepatic insulin production is expected to stimulate glycogen storage. However, the effect of HIGT on hepatic glycogen metabolism __in vivo__ is unknown. ## Methods After administration o