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Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein

✍ Scribed by Zhou, Xiao Yan; Shibusawa, Nobuyuki; Naik, Karuna; Porras, Delia; Temple, Karla; Ou, Hesheng; Kaihara, Kelly; Roe, Michael W; Brady, Matthew J; Wondisford, Fredric E


Book ID
109931582
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
523 KB
Volume
10
Category
Article
ISSN
1078-8956

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Cultured hepatic stellate cells (HSCs), the cell type primarily involved in the progression of liver fibrosis, secrete insulin-like growth factor-I (IGF-I) and IGF binding protein (IGFBP) activity. IGF-I exerts a mitogenic effect on HSCs, thus potentially contributing to the fibrogenic process in an