Molecular scanning of the insulin recept
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S. Ura; E. Araki; H. Kishikawa; T. Shirotani; M. Todaka; S. Isami; S. Shimoda; R
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Article
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1996
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Springer
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English
⚖ 989 KB
Since the insulin receptor substrate-1 (IRS-1) is the major substrate of the insulin receptor tyrosine kinase and has been shown to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a potential candidate for development of non-insulin-dependent diabetes m