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Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease

✍ Scribed by G. A. Hitman; K. Hawrami; M. I. McCarthy; M. Viswanathan; C. Snehalatha; A. Ramachandran; J. Tuomilehto; E. Tuomilehto-Wolf; A. Nissinen; O. Pedersen


Book ID
104762533
Publisher
Springer
Year
1995
Tongue
English
Weight
692 KB
Volume
38
Category
Article
ISSN
0012-186X

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Since the insulin receptor substrate-1 (IRS-1) is the major substrate of the insulin receptor tyrosine kinase and has been shown to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a potential candidate for development of non-insulin-dependent diabetes m