Insulin-like growth factors I and II in evaluation of growth retardation
β Scribed by Ron G. Rosenfeld; Darrell M. Wilson; Phillip D.K. Lee; Raymond L. Hintz
- Book ID
- 119461754
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 564 KB
- Volume
- 109
- Category
- Article
- ISSN
- 1097-6833
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Insulin-like growth factor I1 is believed to play an important role in fetal growth and development. The insulin-like growth factor I1 gene expression is tissue specific and developmentally regulated. We have previously shown an enhanced level of insulin-like growth factor I1 messenger RNA and prote
Growth retardation is a cardinal characteristic of Down syndrome (DS). It is most pronounced from the age of 6 months, when growth starts to become growth hormone (GH) regulated. DS children have normal serum levels of GH. GH regulates the production of insulin-like growth factors (IGFs), which act